ANOBOLIC ANDROGENIC STREROIDS  IN MALE ADULTS MICE INDUCED : HYPOTHYRODISIM , OXIDATIVE STRESS

ShaimaObeadAbde,; Ahmed Rahim, AllhShaima

	ANOBOLIC ANDROGENIC STREROIDS IN MALE ADULTS MICE INDUCED : HYPOTHYRODISIM , OXIDATIVE STRESS
Euphrates Journal of Agriculture Science
Article 1, Volume 6, Issue 4, 2014, Pages 16-29
Authors
; AllhShaima Ahmed Rahim
Abstract
Abstract : Thyroid function is affected by AAS used in humans, although the mechanisms of the effects ofandrogenic anabolic steroid (AAS) are unclear. The present study is designed to know the effect of AAS in thyroid function and oxidative stress. Experimental animals used in the study(30 Swiss mice) were allocated to three groups as general control group, and test groups(N=10). The test groups received (5,10) mg/kg of body weight nandroloneDecanoate by subcutaneous injection each 48 hours , but control groups received the same volume of normal saline . The duration of the experiment was 4-weeks. Blood samples were collected after two days at the end of experimental period from the control and treated groups. The serum samples were assayed for (TSH,T3,T4, total cholesterol , MDH,GSH,) Results revealed that all ND-treated animals exhibited a significant increase of body weight (B.W) and serum TSH hormone, total cholesterol, MDA, a significant decrease was found in GSH level,T3 and T4 hormone, Our data of this study indicate that anabolic steroids at supraphysiological doses exerts direct actions on the thyroid gland and might lead to thyroid dysfunction and increase of oxidative stress of males .Testosterone or its derivatives such as NandroloneDecanoate are being problem commonly. Athletes, coaches, and physicians should be aware of their harmful side effects.

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