Role of SalivaryTumor Necrosis Factor-alpha and Immunoglobulin-Ain Recurrent Aphthous Stomatitis

M. Saliah, Mustafa; H Al-Ghurabei, Batool

	Role of SalivaryTumor Necrosis Factor-alpha and Immunoglobulin-Ain Recurrent Aphthous Stomatitis
Journal of the Faculty of Medicine
Article 1, Volume 53, Issue 2, 2011, Pages 207-210
Authors
Mustafa M. Saliah; Batool H Al-Ghurabei
Abstract
Background:Until today, the etiology of recurrent aphthous stomatitis (RAS) remains unknown, although hints of its etiologic basis lay on genetic susceptibility, infectious agents and alterations in immune mechanics.Objectives:The aim of this study was to investigate the possible alterations in salivarytumor necrosis factor-alpha (TNF-α) and Immunoglobulin-A (IgA) level in patients with RAS and its relation with clinical types of disease.Subjects and Methods:Salivary TNF-αlevels were investigated in50 RAS patients and 25 healthy controls by enzyme-linked immunosorbent assay (ELISA). Single radial immune diffusion method was used for estimation ofIgAlevel in two studied groups.Results:Salivary level of TNF-α was significantly higher in RAS patients than in healthy controls (p<0.001), Moreover, the level of TNF-α was significantly increased in minor type of disease than in major and herptiform types (p<0.05).On the other hand, the levelof IgA showed no significant differences between patients and healthy controls and neither among clinical types of disease(p>0.05).Conclusion: These findings suggestthat saliva provides an ideal medium for the detection of pro-inflammatory markers of the oral cavity, moreover; salivary TNF-α may play an important role in pathogenesis of this disease and it may also have an important role in the search of new treatments for this disease. As well as these results indicated to a possible role of mucosal immune system in pathogenesis of RAS.
Keywords
recurrent aphthous stomatitis; salivary TNF; salivary Immunoglobulin

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