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New spectrophotometric determination of Ranitidine Hydrochloride in different pharmaceutical samples | ||
| Iraqi National Journal Of Chemistry | ||
| Article 1, Volume 0, Issue 56, 2014, Pages 357-366 | ||
| Authors | ||
| Sadiq Jaafer Baqir; Abbas N Alshirifi; Amneen Mohammed Alsayegh | ||
| Abstract | ||
| Abstract Simple ,rapid ,accurate and sensitive spectrophotometric method have been developed for the determination of ranitidine-HCl in pharmaceutical preparations. The method based on complex formation between Ranitidine-HCl and Copper(II) in acetonitrile solvent to yield a green colored complex with a maximum absorbance at 412 nm. Beers law is obeyed in the concentration range of (0.5-12) μg.mL-1; The molar absorpitivity and sandell sensitivity are (8.772 *103) 〖L .mole〗^(-1).cm^(-1), (0.04) μg. cm-2 respectively. Optimisation of the analytical parameters is achieved where; the optimum temperature is (12-50) ̊C, and the optimum time to complex formation is 15 min. Standard deviation, relative standard deviation, limit of quantification LOQ, limit of detection LOD were found to be in the range of (1.2*10-3), (0.324)%, (0.08) μg.mL-1, (0.0264) μg.mL-1 respectively. The proposed method was successfully applied to the analysis of the studied drug in pure and pharmaceutical dosage forms with good accuracy,the recovery percentages Re%, and relative error percentage Erel% were found to be (101±0.58)%, (1.58)% for pure drug and (102±0.80)%,(2.58)% for pharmaceutical dosage. | ||
| Keywords | ||
| Ranitidine hydrochloride; copper; Spectrophotometry | ||
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