EFFECT OF SODIUM FLUORIDE (NaF) ADMINISTERED TO FEMALE MICE ON FERTILITY OF THEIR  MALE OFFSPRING

J. Al-Mufraji, H.; M-R. Fakhrildin, M.; M. H. Shubber, A.

	EFFECT OF SODIUM FLUORIDE (NaF) ADMINISTERED TO FEMALE MICE ON FERTILITY OF THEIR MALE OFFSPRING
IRAQ JOURNAL OF AGRICULTURE
Article 1, Volume 12, Issue 1, 2007, Pages 0-0
Authors
H. J. Al-Mufraji; M. M-R. Fakhrildin; A. M. H. Shubber
Abstract
The present study was conducted to identify the effect of sodium fluoride (NaF) administered to female mice in drinking water on fertility of their male offspring. In this study, Sixty four mature female mice were divided into four major groups according to the dose of NaF as control group (0 ppm), T1(200 ppm), T2(400 ppm) and T3(600 ppm) of NaF. Each major group was subdivided into two minor groups depending on the NaF administration period (10 and 15 weeks). Each minor group contain eight female mice. Weights, number of death and behavior of females and their male offspring mice were studied, as well as, weight of testes, sperm function tests (SFTs), diameter of seminiferous tubules were assessed. Results of this study showed increasing percentage of female and their male offspring death and reduction in weights. Also, results showed reduction in absolute testicular weights, all parameters of SFTs and diameters of seminiferous tubules for both of NaF administration periods 10 and 15 weeks. It can be concluded that the NaF administration to female mice have harmful effects on fertility of their male offspring

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