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The Effects of Green Tea Extract on Liver and Kidney Functions in The Sprague–Dawley Male Rats Treated with Lead Nitrate | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 12, Issue 1, 2015, Pages 215-224 | ||
| Authors | ||
| Ekhlass H. AL-Alasde; Hameda Abd-Al Mahdi G | ||
| Abstract | ||
| Green tea has become a subject of interest because of its beneficial effects on human health, health hazards from increased Pb exposure as a result of industrial and environmental pollution are recognized. In this study, the effect of green tea extract (GTE) on lead nitrate induced toxicity was conducted to investigate the biochemical and histopathological effects on liver and kidney in Sprague–Dawley rats. Four groups of rats were used in this study, 6 animals in each group. First group was given distilled water, second group was given green tea, third group was given lead and forth group was given Lead and GTE orally to the rats with drinking water for 8 weeks, blood sample were collected and then animals sacrificed for histological test. Liver enzymes ALT, AST and ALP, and creatinin , urea for the kidney in the serum, determinations indicated the protective effects of green tea extract. Histopathological studies of liver and kidney revealed that supplementation of green tea extract resulted in mild tissue damage, decrease the inflammation, an enhanced Immunological reaction and regenerative capacity of the cells. | ||
| Keywords | ||
| Green tea extract; lead nitrate; Liver; kidney; Rats; Histopathological changes | ||
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