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Serum Vascular Endothelial Growth Factor VEGF and Interlukin-8 As a Novel Biomarkers For Early Detection of Ovarian Tumors | ||
| Baghdad Science Journal | ||
| Article 1, Volume 12, Issue 2, 2015, Pages 293-300 | ||
| Authors | ||
| Maisaa G. Jumaa; Khalid A. Habib; Munther J. Hussein | ||
| Abstract | ||
| Epithelial ovarian cancer is the leading cause of cancer deaths from gynecological malignancies. Angiogenesis is considered essential for tumor growth and the development of metastases. VEGF and IL−8 are potent angiostimulatory molecules and their expression has been demonstrated in many solid tumors, including ovarian cancer. VEGF and IL-8 concentrations were measured by ELISA test (HumanVEGF,IL-8). Bioassay ELISA/ US Biological / USA). The median VEGF and IL-8 levels were significantly higher in the sera of ovarian cancer patients than in those with benign tumors and in healthy controls. Pretreatment VEGF and IL-8 serum levels might be regarded as an additional tool in the differentiation of ovarian tumors. | ||
| Keywords | ||
| Ovarian cancer; VEGF; Serum | ||
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