- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Synthesis of Prodrug Polymer as Ring Opening of PVP | ||
| Engineering and Technology Journal | ||
| Article 1, Volume 33, 2B, 2015, Pages 252-258 PDF (383.84 K) | ||
| DOI: 10.30684/etj.33.2B.9 | ||
| Authors | ||
| Firyal Mohammed Ali; Halah Hamid Humadi; Luma Amer Mussa | ||
| Abstract | ||
| In this work a new drug polymer was prepared from reaction of polyvinylpyrrolidone (PVP) with doxycylin in 10:1 dioxane: dimethelyformad solvent mixture. The prepared drug polymer was formed with 85% conversion percentage. The physical properties were studied and intrinsic viscosity was equal to 0.23 dl/g. The drug polymer was characterized by FT-IR and UV spectroscopy. The swelling % was studied in different non solvents. The elemental analysis and DSC were analyzed. The controlled release rates for drug polymer were studied in different pH values at 37oC for 4 days. The softening point of the prepared doxycyclin drug polymer was 143.4oC to 150.3oC with ΔH=-189.89 J/g. | ||
|
Statistics Article View: 336 PDF Download: 246 |
||