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Evaluation of Vitamin D Status in Patients with Type 1 Diabetes Mellitus | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 26, Issue 1, 2015, Pages 15-19 | ||
| Author | ||
| Abdilkarim Yehia J. AL-Sammraie | ||
| Abstract | ||
| Type 1 diabetes mellitus (T1DM) is an autoimmune disease which usually occurs early in life. Some researchers have been interested in a potential link between T1DM and vitamin D due to its ability in making the immune system smarts. The aim of this study is to assert the relationship between the severity and frequency of vitamin D deficiency and risk of developing T1DM in children and adolescents. Eighty (80) T1DM children and adolescents were studied, fasting plasma glucose, HbA1C, fasting plasma insulin, serum 25(OH) vit.D3, Ca, PO4, alkaline phosphatase, in addition to HOMA-IR and BMI were measured for these diabetic patients. These patients were compared with eighty (80) healthy children and adolescents age and sex matched. Thirty two(40%) diabetic patients were 25 (OH) vit.D3 deficient, forty eight (60%) patients had normal levels, and fifteen (18.75%) of the control group were 25(OH) vit.D3 deficient, sixty five (81.25%) had normal levels. Vitamin D levels were not significantly lower in diabetic patients compared to control group (23.1±7.2 vs. 24.8 ± 6.9 ng/mL). Serum Calcium of diabetic patients was significantly lower whereas serum phosphorous significantly higher (8.0±1.7 vs. 10.2 ±1.3 mg/dL), (5.2±1.3 vs. 4.0±1.1 mg/dL)(p< 0.01) respectively. Vitamin D levels correlated negatively with BMI (r= - 0.527, p< 0.01) and positively with diabetes duration( r= 0.449, p< 0.01) for those diabetic patients. Vitamin D deficient diabetic patients had significantly higher HOMA –IR and short duration in comparison to patients with normal vitamin D levels (3.3± 0.9 vs. 1.9± 0.5) (10±3.7 vs. 35±12.5 months) (p< 0.01)respectively. The present study show that vitamin D deficiency prevalence was higher in children and adolescent T1DM in comparison to healthy controls | ||
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