The effectiveness of vaginal lisuride in the treatment of hyperprolactinemia

Abdul Khaliq Nassir, Hind

	The effectiveness of vaginal lisuride in the treatment of hyperprolactinemia
Mustansiriya Medical Journal
Article 1, Volume 14, Issue 1, 2015, Pages 14-17
Author
Hind Abdul khaliq Nassir
Abstract
Background: hyperprolactinemia is a disorder which may be represented clinically by one or more of the following: galactorrhea ,infertility , oligmenorrhea , amenorrhea, luteal phase defect and hirsutisim, lisuride drug was recently used vaginaly in the treatment of hyperprolactinemia to decrease the side effects by it's use orally . Patients & Methods: An interventional study conducted over a period of one year from October 2011 to October 2012 , in Al-Yarmok Teaching Hospital ,50 patients presented with one or more of the following symptoms, abnormal menstrual cycle(amenorrhea,oligmenorrhea), infertility(unovulatory), galactorrhea. All the 50 patients with elevated prolactin level were received lisuride (dopergin) 0.2 mg vaginally at bed time and continued for 12 weeks ,serum prolactin was measured at 8,12 weeks with monitoring of ovulation by serial U/S. Results: The study include fifty patients with mean age was 27.2years ±SD7.01 ,and there mean weight was 62.1kg ±SD9.08 All 50 patients had elevated serum prolactin level with mean 66.1ng/ml ±SD 15.5,at the end of the treatment the range of serum prolactin level between 6-17ng/ml ± SD2.9 , which was significantly lower than pre treatment level P =0.0001 At the end of the treatment 86% achieved regular cycle , Ovulation occur in significant number of patients p value < 0.01, (37.5%) of them get pregnancy .less side effect compared to oral lisurid Conclusion: Vaginal lisurid is an effective drug used for the treatment of hyperprolactinemia to avoid the discontinuation of the drug because of it's side effect, when given orally.
Keywords
lisurid; hyperprolactinemia; Infertility

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