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Adenosine Deaminase Activity and Peripheral Immune Cells Ratios in a Sample of Inflammatory Bowel Disease Patients | ||
| Mustansiriya Medical Journal | ||
| Article 1, Volume 14, Issue 1, 2015, Pages 70-73 | ||
| Author | ||
| Sahar Manfi Ahmad | ||
| Abstract | ||
| Seventy inflammatory bowel disease (IBD) patients (35 ulcerative colitis; UC and 35 Crohn's disease; CD) and 20 controls were investigated for serum level of adenosine deaminase (ADA) and neutrophil-lymphocyte and monocyte-lymphocyte ratios. The results revealed that the mean of ADA was significantly increased in UC and CD patients (46.72 ± 8.99 and 41.17 ± 5.95 ng/ml, respectively) compared to controls (20.85 ± 2.79 ng/ml), but it was also significantly higher in UC patients than in CD patients. The neutrophil-lymphocyte ratio mean was also significantly increased UC patients (5.83 ± 3.10) as compared to CD patients (3.79 ± 2.02) or controls (1.66 ± 0.22). The ratio was also significantly increased in CD patients compared to controls. A similar pattern was also observed in monocyte-lymphocyte ratio. In conclusion ADA may have a role in the pathogenesis of IBD, especially UC, and consequently the peripheral immune cells might have been affected. | ||
| Keywords | ||
| Inflammatory bowel disease; ulcerative colitis; Crohn; adenosine deaminase | ||
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