Assessment of Plasma FXII:C in pregnant women with severe preeclampsia

F.Alwan, Alaa; M. Zubair, Alauldeen; W. Salman, Shaymaa

	Assessment of Plasma FXII:C in pregnant women with severe preeclampsia
Mustansiriya Medical Journal
Article 1, Volume 14, Issue 1, 2015, Pages 79-84
Authors
Alaa F.Alwan; Alauldeen M. Zubair; Shaymaa W. Salman
Abstract
Background:Preeclampsia is a complication of pregnancy constituting a major cause of both maternal and fetal morbidity and mortality. Pregnancy is a hypercoagulable state with changes in procoagulant, anticoagulant, and fibrinolytic systems. In preeclampsia, there is a shift in the haemostatic balance towards a pro-thrombotic state, together with changes in endothelial function. It is a state of enhanced coagulation as evidenced by an increased amount of clotting factors in maternal circulation. Aim of the study:•To study the changes in FXII:C activity in pregnant women suffering from severe preeclampsia, and compared with healthy normotensive pregnant women. •To correlate its level with the severity of preeclampsia. Patients and Methods: Thirty five pregnant women in the third trimester of pregnancy with severe preeclampsia were collected from the Department of Obstetrics and Gynaecology in AL-Yarmouk Teaching Hospital from July to October 2010. Their age range is 18-41 years. The criteria for severe preeclampsia included sustained blood pressure of 160/110 mmHg or higher with persistent proteinuria of 2+ or greater on urine dipstick. A total of thirty five healthy pregnant women who were not in labour, their age and gestational age matched with the patients and normotensive throughout gestation were included as a control group. Blood samples were taken from both groups. Four ml of citrated plasma was isolated for PTT, and FXII:C assay [by parallel line bioassay of coagulation factors]. Results: There was significant difference in mean PTT between patients with severe preeclampsia (27.17±4.11) and control group (31.40±4.53). (P value < 0.0001).There was significant difference in mean FXII:C between patients with severe preeclampsia (173.29±8.82) and control group (131.85±9.78). (P value < 0.0001). Conclusions: Factor XII:C was significantly increased in patients with severe preeclampsia than control group and show significant direct linear correlation with the severity of preeclampsia. Activated Partial Thromboplastin Time was significantly shorter in patients with severe preeclampsia than control group.
Keywords
factor XII; Preeclampsia

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