- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Design, Synthesis and Preliminary Antimicrobial Evaluation of New Derivatives of Cephalexin | ||
| Iraqi Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 24, Issue 1, 2015, Pages 85-91 | ||
| Authors | ||
| Sarrah S. Jabbar; Shakir M. Alwan | ||
| Abstract | ||
| There is a continuous and massive need for newer cephalosporins that should have resistance against β-lactamases and can be used orally. An approach of using cephalexin, as a well-studied and potent antibacterial compound is considered to prepare new designed derivatives. These derivatives include the incorporation of amino acid moiety linked through an amide bond with the α-amino group of cephalexin. Certain aliphatic amino acids were used, such as glycine, alanine, valine and proline. The chemical structures of these derivatives were confirmed by IR spectroscopy and elemental analyses. All the synthesized compounds were subjected for the evaluation of antimicrobial activity using well diffusion method, against certain microbes. Most of the synthesized compounds were found to possess significant antibacterial activities. Compound 1 (125 μg and 250μg) showed significant activity against P. aeruginosa. Compound 2 (125 and 250μg) exhibited significant activity against P. aeruginosa and Bacillus cereus. Compound 3 (125 and 250μg) demonstrated very significant activity against E. coli, P. aeruginosa and Bacillus cereus and slight activity towards S. aureus. Compound 4 (250μg) showed significant activity against P. aeruginosa and no antibacterial activities against E. coli, S. aureus and Bacillus cereus, as compared with cephalexin as the standard compound | ||
| Keywords | ||
| Cephalosporins; Cephalexin; Glycine; Alanine; Valine; proline | ||
|
Statistics Article View: 144 PDF Download: 5 |
||