Study of Some Serological Tests on Patients with Visceral Leishmaniasis

Salim Musa, Israa

	Study of Some Serological Tests on Patients with Visceral Leishmaniasis
Iraqi Journal of Science
Article 1, Volume 56, Issue 1, 2015, Pages 645-648
Author
Israa Salim Musa
Abstract
This study aimed to measure the alterations in serum zinc (Zn) and acute phase proteins ( C-reactive protein and Ceruloplasmin) concentrations in patients with visceral leishmaniasis (VL). A total of 62 individuals were enrolled in this study : 52 individuals were infected with visceral leishmaniasis and 10 individuals as healthy control. Serum zinc levels were significantly (p<0.05) decreased in patient group(76.25 ± 4.59 µg/dl ) when compared with healthy control (103.75 ± 3.77 µg/dl ) . C-reactive protein , as a mediator of innate immunity, removed damaged cells by activating the classical complement pathway revealed elevated levels in patients (4.36± 0.23mg/l ) when compared with the healthy control (2.50 ± 0.28mg/l ). The level of Ceruloplasmin was also significantly (p<0.05) increased in VL patients (0.82±0.05 mg/dl) as compred with healthy subjects (0.43±0.03mg/dl). These results showed that serum essential trace elements Zn, C-reactive protein and ceruloplasmin concentrations have been changed in VL patients. This may be a part of defense strategies of organism
Keywords
Visceral leishmaniasis; Zinc; CRP; Ceruloplasmin

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