- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Study of the Protective Effects of Ginger Extracts Against Induced by Carbon Tetrachloride in Rats. | ||
| Magazine of Al-Kufa University for Biology | ||
| Article 1, Volume 7, Issue 1, 2015, Pages 19-34 | ||
| Authors | ||
| Zainab Sajid Al-Shemmari; Haider Salih | ||
| Abstract | ||
| The present study was designed to evaluate the possible hepatoprotective and Antioxidant activity of ethanol and aqueous extracts of Zingiber officinale using carbon tetra chloride (Ccl4 )- induced hepatotoxicity in rats. The study was conducted of 42 male rats; the animals were allocated into 6 groups (7 rats in each group) and treated as follow: groupI treated with oral doses of normal saline and saved as a control; groupII treated with 0.5 ml of volume dose oral doses of Ccl4 suspended in olive oil doses of Ccl4 suspended in olive oil (1:1, v/v) 0.5ml at 3 days in week; group III treated with 0.5 ml of volume dose from Ccl4 plus ethanolic extract at concentration 300 mg/kg at the same time; group IV treated 0.5 ml of volume dose from with Ccl4 plus ethanolic extract at concentration 150 mg/kg at the same time ; group V treated with 0.5 ml of volume dose from Ccl4 plus aqueous extract at concentration 300 mg/kg at same time; group VI treated with 0.5 ml of volume dose from Ccl4 plus aqueous extract at concentration 150 mg/kg at the same time; at the end of treatment period (8 weeks), rats were scarified, blood sample obtained for assessment of oxidative stress parameters and antioxidant parameters MDA , GSH and vitamin C. Additionally, serum levels of ALT and AST were evaluated after and before treatment, the result indicated that ethanol extract at concentration 300mg/kg has the ability to a significant decrease (p<0.05) in activities of serum liver enzyme AST, ALT , vitamin C , and MDA level, a significant increase (p<0.05)in GSH level . The results of this study indicate that the two concentrations(150, 300)mg/kg of the ethanolic Zingiber officinale rhizomes extracts gave a good results, even better than aqueous extract. | ||
| Keywords | ||
| hepatoprotective; Antioxidant activity; Zingiber officinale; officinale | ||
|
Statistics Article View: 52 PDF Download: 19 |
||