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Immunological and Hormonal Changes in Thyroid Goiter Patients in Correlation with Histopathological Types | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 12, Issue 2, 2015, Pages 413-420 | ||
| Authors | ||
| Enas A. Abbas; Hadi M. AL-Mosawi; Hussein N. Al-Shammary | ||
| Abstract | ||
| The patients with thyroid goiter presented in hyperthyroidism, hypothyroidism or euothyroid state, included multinodular goiter (MNG), Hashimoto thyroiditis and thyroid tumor, these type of diseases suffering from different immunological changes in correlation with thyroid function test and histopathological types. The present study was conducted in Hilla city from November 2013 to August 2014. This study was included 101 cases dividing into three groups according to the histopathological diagnosis after total thyroidoctomy. The first group included sixty eight cases of MNG patients, the second group included nineteen cases of patients with thyroid tumor, and the third group included fourteen cases of patients with thyroiditis. For all cases, thyroid function test, the immunological analysis studies included immunoglobulins (Igs) and complement componants were done. Results of present study were showed that the IgM was highest among patients with MNG meanwhile; the mean IgA was highest among patients with thyroid tumor. The mean IgG was highest among patients with MNG. There were significant associations between thyroid diseases and IgA, IgG and C3, p<0.05. Other result show the mean C3 was highest among patients with tumor changes meanwhile; the mean C4 was highest among patients with tumor changes. Also other result show there was significant association between thyroid diseases with TSH, patients with thyroiditis were most likely to be hypothyroidism, p<0.05. The aim of study to determine the types of immunological changes in correlation with histopathological types and hormonal changes. So as the immunoglobulin level (Ig) was high in different types of thyroid disease especially IgG. The complement component (C3) level was high in different thyroid disease, while the C4 level was low in different thyroid diseases. | ||
| Keywords | ||
| Multinodulear goiter; Hashiomto thyroiditis; immunoglobulin; Thyroid function test | ||
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