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The Cytotoxicity Effect of Ethanolic Crude Extract of Cnicus benedictus Leaves on the Murine mammary adencarcinoma Cell Line AMN-3 | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 8, Issue 1, 2015, Pages 72-78 | ||
| Authors | ||
| Youssef Shakuri Yasin Al-Samarray; Shalal Murad Hussian Al-Ataby; Saleh M.Rahem | ||
| Abstract | ||
| This study aimed to investigate the effects of Ethanolic crude extract Cnicus benedictus leaves on the proliferation of the cancer cell line (AMN-3), as it has been taking the start of the decimal concentrations (1,10,100,1000,10000) µgm / ml, showed there was no inhibition at concentrations (1,10,100) µgm / ml, less than 50%, but there are significant differences between the concentrations, either concentrations (1000, 10000) µgm / ml inhibition rate was more than 50%, reaching respectively damping ratios (76.2 , 50. 6)% at after 24 hrs. The study found the presence of toxic effect murderer to extract ethanolic plant at concentrations approved, concentrations (1000 , 10000) µgm / ml, followed by the inhibitory results when after 72 hrs., the concentration (10000) µgm / ml, with total inhibition rate (40.9%) as well as at the same concentration came When the damping ratio less time after 48 hrs., amounting to increase (31.7 (%.. The comparisons horizontal statistical between concentrations three times susceptibility, the results for ethanolic of the leaves showed that the time after 24 hrs. was more times influence inhibition as the concentrations (1000, 10000) µgm / ml high significant rates discourage respectively (76.2 , 50.6%) compared to concentrations interview at other times, as well as the difference was significant at after 72 hrs. of concentration (100) µgm / ml compared to the times the other for the same concentration, increase at after 72 hrs. were not any obvious differences in terms of results indicated that the damping ratios of concentrations (1 , 10) µgm / ml It showed no significant differences for the three times. It was obtained on these results it can be concluded that this plant blessed thistle is one of the most promising medicinal plants with the active role in the treatment of cancer through its influence inhibitory and toxic effects of cancer cells. | ||
| Keywords | ||
| Effect extracted of Cnicus benedictus on cancer cell line AMN; Cnicin; Cnicus benedictus | ||
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