The protective effect of alcoholic extract of Zingiber officinale Rosc. (Ginger) on body weight , fertility and some of biochemical parameters of blood at females albino rats that treated with Paracetamol (Acetaminophen) drug.

Mahmood Jwad, Saher

	The protective effect of alcoholic extract of Zingiber officinale Rosc. (Ginger) on body weight , fertility and some of biochemical parameters of blood at females albino rats that treated with Paracetamol (Acetaminophen) drug.
Magazine of Al-Kufa University for Biology
Article 1, Volume 7, Issue 2, 2015, Pages 0-0
Author
Saher Mahmood Jwad
Abstract
The present research was performed in the animal house of biology department / Faculty of Education for Girls, aimed to study the effect of alcoholic extract of Zingiber officinale Rosc. on body weight , fertility and some of biochemical parameters of the blood at females albino rats that treated with Paracetamol drug, and included the follow up (32) females of albino rats were sexually matured at three months age. For this study to carry out, the animals were divided randomly into four groups, eight females for each group, the first group (I) was given normal saline as a control group, the second group (II) was given the concentration( 7.5) mg/kg of Paracetamol drug, while the third group (III) was first given the concentration(500) mg/kg of alcoholic extract of Zingiber officinale Rosc. , and after one hour the same group was given Paracetamol drug at the concentration(7.5)mg/kg. As while as the forth group (IIII) was given Zingiber officinale Rosc. alcoholic extract at the concentration( 500 )mg/kg. The dosage process was continued orally for 21 days (for five respective estrus cycles) once daily. The results were revealed: the dosage with Paracetamol drug was showed a significant decrement (P < 0.05) in body weight, ovary weight, ovarian follicles diameters and their numbers, concentrations of gonadotropin releasing hormones (FSH and LH), ovarian hormones (estrogen and progesterone), thyroid hormones (T4 and T3), erythropoietin and glutathione (GSH) in the serum. In the contrast of that the treatment with drug was caused a significant increment (P < 0.05) in concentrations of thyroid stimulating hormone (TSH) and malondialdehyde (MDA) in comparative with the control group and other groups. On the other hand, the injection with alcoholic extract of Zingiber officinale Rosc. was showed antagonistic effect to the physiological action of Paracetamol drug through the significant increase (P < 0.05) in: body weight, ovary weight, ovarian follicles diameters and their numbers, concentrations of: FSH, LH, estrogen, progesterone, T4, T3, erythropoietin and GSH in the serum, and the significant decrease (P < 0.05) in concentrations of TSH and MDA when compared with the control group and the group that treated with Paracetamol drug. The present study was concluded to: the alcoholic extract of Zingiber officinale Rosc. was revealed a protective effect on cells and body tissues especially ovaries of rat females which treated with Paracetamol drug, so we recommend to use it as a nutritional or remedial supplement at the treatment with Paracetamol drug.
Keywords
Alcoholic Extract; Zingiber officinale Rosc; Fertility; Females albino rats; Paracetamol drug

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