Experimental Infection with bovine parainfluenza type 3 virus in mice

Bara Allawe, Aida; Sabri Al-Bana, Anton

	Experimental Infection with bovine parainfluenza type 3 virus in mice
The Iraqi Journal of Veterinary Medicine (IJVM)
Article 17, Volume 39, Issue 1, 2015, Pages 81-84 PDF (0 K)
Authors
Aida Bara Allawe; Anton Sabri Al-Bana
Abstract
Four weeks old mice were used for experimental infection with isolated bovine parainfluenza type 3 virus. Mice were divided into three groups: The first group was infected by intracerebral route, the second group was infected by intranasal route and the third group was a control group. Experimental infection with isolated bovine parainfluenza type 3 virus in mice revealed that the isolated BPIV-3 was unable to kill 4 weeks old mice within 65 days when inoculated by intracerebral route, but isolated BPIV-3 was shown to kill (5 out of 10) 4 weeks old mice within 65 days when inoculated by intranasal route. There was no mortality in the control group within the same period. Two weeks old mice were used for experimental infection with isolated bovine parainfluenza type 3 virus and histopathological examination of infected organs was performed. Experimental infection of 2 weeks old mice by isolated BPIV-3 revealed that isolated BPIV-3 induced hydrocephalus after intracerebral inoculation. Histopathological examination for collected organs of BPIV-3 infected 2 weeks old mice (brain and lung) indicated histopathological changes were detected in comparison to non-infected collected organs. Virus was reisolated from infected brains of experimentally infected mice with locally isolated BPIV-3.
Keywords
Bovine parainfluenza; Viruse; mice

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