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Spectrophotometric Determination of Metochlopramide in itsPharmaceutical Preparations using Diazotization Coupling Reaction | ||
| Iraqi National Journal Of Chemistry | ||
| Article 1, Volume 15, Issue 2, 2015, Pages 175-190 | ||
| Authors | ||
| Wasan Abdulameer Al-Uzri; Hind Hadi; Ghadah Fadhel | ||
| Abstract | ||
| ABSTRACT: Simple and direct spectrophotometric method for quantitative estimation of metoclopramide hydrochloride (MTP) in pure and pharmaceutical dosage forms was adopted. The established method is based on a diazotization coupling reaction between diazotized MTP with new coupling reagent, 7-iodo-8-hydroxyquinoline5-sulphonic acid in alkaline medium. An intense red, water-soluble dye that is very stable and has a maximum absorption at 510 nm had been obtained. Regression analysis of Beer’s law plot showed good correlation in the concentration range 0.4-12μgml-1 with a molar absorbtivity of 1.91×105 L mol-1cm-1 and Sandell's sensitivity of 0.0018g.cm-2. The proposed method was successfully applied to the determination of MTP in its pharmaceutical formulations. | ||
| Keywords | ||
| Metochlopramide; Diazotization Coupling Reaction; iodo; hydroxyquinoline; sulphonic | ||
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