Molecular and Immunological study of Cutaneous Leishmania in Karbala city

	Molecular and Immunological study of Cutaneous Leishmania in Karbala city
journal of kerbala university
Article 1, Volume 11, Issue 0, 2015, Pages 34-47 PDF (0 K)
Abstract
This study was conduct to investigation the infections of Cutaneous Leishmania in karbala city , (73) of infections were in (2010-2011) and (125) were in (2011-2012) with ratio 58.4 % and 41.6 % respectively . The infections were distributed according to the inhibited areas of karbala governorate of following . 51 (40.8%) in EinAl-Tamir , 29 (23.2%)in Al-Husseinya , 17 (13.6%) in Al-Hur , 16 (12.8%) in the south quarters, 7 (5.6%) in the north quarters and 5 (4%) in the city center . The immunological study for the patients serums with L. major by ELISA technique has shown significantly raised in values of IgG and IgM during infection in comparison with the control group , then it declined slowly after treatment in which IgG was in mean (1811.1 ± 523.1 mg/dl) , and IgM mean was (166.7 ±23.6 mg/dl). Also, in L. tropica – IgG mean was (1722.1 ± 524.0mg/dl) and IgM was in ratio (25.3±182.9mg/dl) in comparison with control specimens , and then the mean have declined after treatment dosages with Pentostam drug. The cellular dynamics values have shown an significantly increase in which interferon- gamma (IFN-γ) in infected patients with cutaneous L. major were (5.5±113.2mg/dl) which declined after treatment abstractly to (3.0±6.05mg/dl) as well as for L. tropica (6.5±88.2 mg/dl) which shows no significant abstract difference after treatment with control . An increase appears in cytokine IL-10 that reached in L.major (9.8±215.0mg/dl) and after treatment was (5.1±9.02mg/dl) and in L. tropica was (8.8±115.0mg/dl) with no significant difference after treatment with control specimen .

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