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Correlation between virulence factor and biofilm formation in Proteus spp. | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 56, Issue 2, 2015, Pages 1675-1681 | ||
| Authors | ||
| Sarah S.Qaddoorri; Bahaa A. Laftaah; Murtada N. AbdALgani; Rabab K.AL-Segar; Alaa M.Raoof; Sawsan S.Abd-ALkadir; Yousra J.Ali; Tahreer H.A -Neddawi | ||
| Abstract | ||
| Urinary Tract Infection is an infection that caused by the members of the genus Proteus that depends mainly on the availability of virulence factors ;Various virulence factors including biofilm, swarming migration , polysaccharide ,heamolysin,protease, DNase, urease production weredetermined for 45Proteus isolates that obtained from clinical specimens of Urinry Tract Infection patient . The distribution of virulence factors was showed variation among the testedisolates and strain specific in most cases. All Proteus isolates showed 45 (100%)biofilm , polysaccharide andSwarming capabilities with different extents. High ureaseproduction was demonstrated in most isolates 40 (88.8%);In addition, they were abling to produce protease,DNase and heamolysin, in 30(66.6%) , 28 (62.2%) and26(57.7%) respectively. The result of susceptibility test for Proteus spp. against seven antibiotics commonly used to treat UTI infection caused by Proteus spp. ; P.mirabilis were 90% sensitive for Meropenem , 80% to Ciprofloxacin , 60% for both Cephalothin , Nitrofurantion , 50% , 40% and 30% for Amikicin, gentamicin and ceftriaxone respectively ,butP.vulgaris isolates were sensitive to 80% for Meropenem ,70% Ciprofloxacin and Nitrofurantion and sensitive to 60%,50% ,40 % and 30 % for Cephalothin, gentamicinAmikacinand ceftriaxone respectively.(This studyaimed to detect and evaluate the presence of some virulence factors in Proteus species isolates causing Urinry Tract Infection . | ||
| Keywords | ||
| biofilm; Swarming; DNase | ||
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