Evaluation of Some Genetic Factors in Rheumatoid Arthritis patients in Iraq

K. Al-Mousawi, Jaafar; M.Al- Mohana, Ali; K. Al, Israa; Yasiri,

	Evaluation of Some Genetic Factors in Rheumatoid Arthritis patients in Iraq
Iraqi Journal of Biotechnology
Article 1, Volume 13, Issue 2, 2014, Pages 66-74
Authors
Jaafar K. Al-Mousawi; Ali M.Al- Mohana; Israa K. Al;
Abstract
Rheumatoid arthritis (RA) is a chronic, destructive autoimmune disease affecting the joints. With more sophisticated and effective therapies becoming available and with the understanding that early intervention is crucial in preventing irreversible joint damage. The main purpose of this observational study was to evaluate and detects a good genetic factors may be used in early detection of RA. A total of 40 patients with RA who were fulfilled four or more of the 1987 American College of Rheumatology (ACR), 20 patients with joints problems (JP), 20 RA patient relatives (PR) and 10 apparently healthy control individuals were included in this study. Human leukocyte antigen (HLA) genotyping was performed using Mr. Spot SSO system. The distribution of HLA class II genotypes in 20 RA patients and 30 control groups were studied. HLA-DRB104 was significantly most common genotypes in the RA patients (70%) compared to control groups (23.3%). While, the frequency of HLA-DRB111 was very high among controls (53.3%) compared to RA patients (25.0%), but the difference was not statistically significant. RA susceptibility in most Iraqi patients was associated with the HLA-DRB104 genotype. The HLA-DRB104 allele contributed significantly to the development of RA .HLA- Therefore, HLA-DRB1*04 allele appears to play an important pathogenic role in all subsets of RA.
Keywords
Rheumatoid arthritis; HLA

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