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The Effect of Caffeine Extracted From Green Tea Camellia Sinensis on Experimental Infection of Entamoeba histolytica in Laboratory Mice. | ||
| Journal of Tikrit University For Agriculture Sciences | ||
| Article 1, Volume 15, Issue 3, 2015, Pages 156-169 | ||
| Authors | ||
| Ilham A. A. Altikrity; Marwan A. H. Aljanabi | ||
| Abstract | ||
| The active compound (caffeine) was isolated from dry leaves of green tea Camellia sinensis , and the isolation confirmed by Fourier transform infrared spectroscopy FTIR, UV/VIS scanning spectrophotometer UV and High Performance Liquid Chromatography HPLC. The caffeine purity was identified by comparing with standard caffeine, the lethal dose LD50 of the caffeine was 125mg/kg after 48 hours of dosage, The results showed the effect of different concentrations of the active compound (caffeine), on the histological changes of the infected mice colon, and on the number of cysts that released with the feces daily for 7 days, these results showed that the infected colon of the treated mice were either recovered to the normal histological condition, or an increase in the number of under laying cells, secretion of high quantities of mucin and few leaching of inflammatory cells. The first concentration of caffeine, showed significant effect in reducing the number of the released cysts among the three concentrations of caffeine, as the percentage of the released cysts after treatment (31.25 %, 50.00% and 81.25%) respectively. | ||
| Keywords | ||
| green tea; Caffeine; parasitic infections; Entamoeba histolytica | ||
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