- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives | ||
| Baghdad Science Journal | ||
| Article 1, Volume 12, Issue 3, 2015, Pages 546-554 | ||
| Authors | ||
| Entesar O. AL-Tamimi; Raad M. Muslih; Khalida A.Thejeel | ||
| Abstract | ||
| New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j). The synthesized Schiff bases were cyclized by chloroacetyl chloride in the presence of triethylamine to form beta-lactam derivatives 3(a-j). The compounds were characterized by deremination melting point, FT-IR and 1H NMR. The beta-lactam derivatives were screened in vitro antibacterial against some bacterial species. | ||
| Keywords | ||
| Cefalexin; Schiff Base; beta; lactam; antibacterial activity | ||
|
Statistics Article View: 149 PDF Download: 9 |
||