K. Ismael, M. (2014). Determination of thyroid hormone levels in the serum of Non- dialyzed patients with chronic renal failure. , 7(3), 8-12. doi: 10.37652/juaps.2013.104794
May K. Ismael. "Determination of thyroid hormone levels in the serum of Non- dialyzed patients with chronic renal failure". , 7, 3, 2014, 8-12. doi: 10.37652/juaps.2013.104794
K. Ismael, M. (2014). 'Determination of thyroid hormone levels in the serum of Non- dialyzed patients with chronic renal failure', , 7(3), pp. 8-12. doi: 10.37652/juaps.2013.104794
K. Ismael, M. Determination of thyroid hormone levels in the serum of Non- dialyzed patients with chronic renal failure. , 2014; 7(3): 8-12. doi: 10.37652/juaps.2013.104794

Determination of thyroid hormone levels in the serum of Non- dialyzed patients with chronic renal failure

Journal of University of Anbar for Pure Science
Article 3, Volume 7, Issue 3, 2013, Pages 8-12    PDF (404.35 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2013.104794
Author
May K. Ismael*
University of Baghdad - College of Science
Abstract
Abstract: Thyroid hormones, triiodothyronine (T3) and thyroxin (T4) play an important role in growth, development, and physiology of the kidney. The kidney has a central role in metabolism and clearance of these hormones as well as thyroid – stimulating hormone (TSH). Chronic renal failure (CRF) is a state of irreversible deceleration in renal function results in alterations in internal milieu, which affects the synthesis and secretory rate of hormones. To evaluate the thyroid hormone levels in non-dialyzed patients with chronic renal failure (CRF); 24 patients with CRF aged 30-70 years, mean±S.d. (48.458 ± 13.569) and 48 healthy volunteers who served as controls aged 30-70 years (43.104 ± 12.387) were studied for their thyroid function status using enzyme-linked immunosorbent assay(ELISA). The study showed significant increase (p<0.05) in the serum triiodothyronine (T3), thyroxin (T4) and thyroid stimulating hormone (TSH) levels in 25%, 20%, and 25% of CRF patients respectively as compared to the healthy groups; while 75% of CRF patients showed non significant low levels (p>0.05) for both T3 and TSH and 80% for T4. Also there was a high positive relation between TSH, T3, T4 levels respectively with both age and gender of chronic renal failure patients. The results suggest that patients with CRF have a state of thyroid dysfunction.
Keywords
Chronic renal failure; Pre; dialysis; Thyroid hormones
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