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Solvent -Free One -Pot Multicomponent, Synthesis, Characterization and Anti-bacterial activity, of some 2-substituted-3-cyano-Pyridine Derivatives | ||
| Ibn Al-Haitham Journal For Pure And Applied Science | ||
| Article 1, Volume 28, Issue 2, 2015, Pages 126-135 | ||
| Authors | ||
| Zakaria H. Aiube; Muna S. Al-rawi; Ahmed K. Ebrahem | ||
| Abstract | ||
| Solvent- free thermal heating, one-pot condensation of acetophenone, ethyl cyanoacetate or malononitrle and substituted Aromatic aldehyde, ammonium acetate give, 2-oxo-3-cyano-4-substituted Aryl-6-phenyl pyridine ]I[a-h , or 2-amino-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives]II[a-f , respectively. Treatment of compounds 2-oxo-3-cyano-4-substituted Aryl-6-phenyl pyridine with phosphorous penta sulphide (P2S5), give 2-thioxo-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives]III[a-c . All prepared compounds are characterized by, C.H.N.S-elmental analysis, melting points, FTIR-and1H-NMR-spectral analysis . Antibacterial examination of synthesized compounds [I]a-c , [II]a-c and [III]a-c against five types of, (G-) and (G+) bacterial . in comparison with common antibiotic like Ampicillin, Amoxicilin and Lincomycin the result shows 2-thioxo-3-cyano-4-substituted Aryl-6-phenyl pyridine derivatives are more reactive than 2-oxo-3-cyano pyridine derivatives or 2-amino-3-cyano pyridine derivatives . | ||
| Keywords | ||
| Solvent; free; One; pot; pyridine derivatives | ||
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