N. J. Al-Darrji, M., Y. Yaseen, N., F. Shehab, A., H. Obaid, H. (2015). The Study of Genetic Variations of GCG Gene and it's Relationship to Obese in Iraqi Population. , 56(3), 1866-1877.
Mustafa N. J. Al-Darrji; Nahi Y. Yaseen; Adil F. Shehab; Hind H. Obaid. "The Study of Genetic Variations of GCG Gene and it's Relationship to Obese in Iraqi Population". , 56, 3, 2015, 1866-1877.
N. J. Al-Darrji, M., Y. Yaseen, N., F. Shehab, A., H. Obaid, H. (2015). 'The Study of Genetic Variations of GCG Gene and it's Relationship to Obese in Iraqi Population', , 56(3), pp. 1866-1877.
N. J. Al-Darrji, M., Y. Yaseen, N., F. Shehab, A., H. Obaid, H. The Study of Genetic Variations of GCG Gene and it's Relationship to Obese in Iraqi Population. , 2015; 56(3): 1866-1877.

The Study of Genetic Variations of GCG Gene and it's Relationship to Obese in Iraqi Population

Iraqi Journal of Science
Article 1, Volume 56, Issue 3, 2015, Pages 1866-1877
Authors
Mustafa N. J. Al-Darrji; Nahi Y. Yaseen; Adil F. Shehab; Hind H. Obaid
Abstract
The present study conducted on 120 obese males and 50 healthy males, their age ranged from 20-50 years. The patients were divided into 3 groups based on Body Mass Index (BMI) and Central Obesity (CO), it has noticed that there is a significant relation between both indexes. The DNA was isolated from the blood of patients and applies for PCR by using designed primers for exons 1 and 3 of GCG gene. The results showed that there are mutants in exon 1 at locus 9573 (G/C) for 30 patients and locus 9864 (C/-) for 10 patients with X2 = 12.30, also it has fund mutants in exon 3 at locus 5397 (A/G) for 28 patients and locus 5434 (G/A) for 8 patients with X2 = 11.11. These mutants have a high significant effect P≤ 0.001 to cause pathogenicity
Keywords
GCG gene; Obesity; glucagon; genetic variations; GCG; GLP
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