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Synthesis and cytotoxic activity study of 3-(2,4-dichlorophenyl)-1-(4'-methoxyphenyl)-3-hydroxypropan-1-one | ||
| basrah journal of science | ||
| Article 1, Volume 33, Issue 1, 2015, Pages 59-68 PDF (0 K) | ||
| Author | ||
| Hanoy K. Al-Amood | ||
| Abstract | ||
| A new methodology was used to synthesis -hydroxyketone compound namly 3-(2,4-dichlorophenyl)-1-(4'-methoxyphenyl)-3-hydroxypropan-1-one directly from -unsaturated compound (p-methoxychalcone) in basic medium. Elemental analysis show good agreement between measured and calculated percentage. FT-IR and NMR Spectra techniques were used to identify structure of prepared compound. Minimum inhibitory concentration(MIC) and cytotoxic activity were investigated. The new compound have a limited ability to inhibit microorganisms but have significant cytotoxicity, | ||
| Keywords | ||
| hydroxyketone; chalcone; aldol reaction; MIC Activity; Cytotoxic activity | ||
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