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Correlation between some immunological parameters and clinicalpresentation in RA patients | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 50, Issue 2, 2008, Pages 235-240 | ||
| Authors | ||
| Samira N. AL- Naim; Eman Sh. AL- Obeidy; Nahida R. Abbas | ||
| Abstract | ||
| Background: Complement (C) & CRP in patients with Rheumatoid arthritis (RA)'could be trigger disease activity. Aim: To study the correlation between C, CRP, IgM,, IgG, IgA & some clinical presentation in RA patients. Methods: Latex agglutination test(AG) & single radial immunoassay(SRIA) were used to asses CRP, IgMJgGJgA,, C, in 74 patients with RA. Results: IgA & IgG were significantly increased, while the mean ofC3, C4 were slightly elevated in RA patients . Conclusion: There is correlation between IgG and IgM with joint deformity and joint swelling respectively, while C3 was showed statistically significant P<0.01 with joint stiffness, joint swelling and Rheumatoid nodule, where as CRP was statistically significant P<0.01withjoint swelling.. Key words : RA.C.CRP, IgM, IgG, IgA, SRI A, AG. Introduction: Rheumatoid arthritis (RA) is one of the mysterious autoimmune diseases which is still unresolved characterized by inflammation of synovial membrane, principally affecting peripheral joints in a symmetric fashion, commonly leads to cartilage destruction, bone erosion and joint deformities; extra-articular manifestations such as vasculitis and subcutaneous nodules can also occur, hence it's course is quite variable (1 -3). | ||
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