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Effect of Ethanol Extract of Root Glycyrrhiza glabra plant on some physiological standards in males white rats treatedwith mutagen (Mitomycin-C) | ||
| journal of kerbala university | ||
| Article 1, Volume 11, Issue 1, 2015, Pages 66-72 PDF (0 K) | ||
| Abstract | ||
| Seventy five white males rats were used in the present study , these animals randomly divided into five groups (15animals per group) the first group was negative control agaved with water second group was positive control dosage oraly with mitomycin – c at 2mg/kg of body weghit for one-month , the third group dosaged with plant extract at 500 mg/kg of body weight two-weeks treatment before the mutagen and for one- month , the fourth group dosaged oraly with plant extract at 500 mg/kg of weight body with mutagen for one- month , the fifth group dosaged oraly with plant extract at 500 mg/kg of weight body two weeks after the treatment mutagen and for one- month , Blood was collected inorder to investigate measured hormones (Te) , (T3) , (T4) , (LH) the results show significant decrease (P>0.05) in hormones for to positive control compared with negative control while standards of liver's enzymes (AST) , (ALT) , (ALP) the results shows significant increase (P< 0.05) in both enzymes AST , ALP while show significant decrease (P> 0.05) in the ALT enzymes while when the interaction between 500 mg/kg of plant extract and mg/kg of MMC was making in three forms of treatment of extract (before , with , after) mutagen MMC to standards hormones, the results show significant decrease (P> 0.05) in both T3 , T4 hormones when treatment with extract (before) mutagen while led to significant increase (P< 0.05) in Te , LH hormones while when treatment by the extract (with) the mutagen leds to significant decrease (P> 0.05) in T3 , Te , LH hormone and occurred significant increase (P< 0.05) in T4 hormones , while treatment (after) the mutagen recorded (P> 0,05) in all hormones while show significant decrease (P< 0.05) in ALP , ALT enzymez also result recorded significant increase (P<0.05) in AST enzymes in used treatments | ||
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