Study The Relationship of IL-33 with Adiponectin in Postmenopausal  Female with and without Type 2 Diabetes Mellitus

Jabbar Hassan, Abeer

	Study The Relationship of IL-33 with Adiponectin in Postmenopausal Female with and without Type 2 Diabetes Mellitus
Medical Journal of Babylon
Article 1, Volume 12, Issue 3, 2015, Pages 618-624
Author
Abeer Jabbar Hassan
Abstract
Postmenopausal women influence by several physiological changes such as coronary artery disease, obesity and insulin resistance. Interleukin-33 (IL-33) a cytokine which have a protective effect to cardiovascular disorders and regarded either pro- or anti-inflammatory. Adiponectin is a hormone with anti-inflammatory properties, associated with hyperlipidemia and insulin resistance. The aim of this study is to investigate the relationships of IL-33, adiponectin with atherogenicity as considered risk factor for heart disease in postmenopausal women with and without type 2 diabetes mellitus. Ninety women age between (54-62) years were enrolled in this study. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), body mass index (BMI), lipid profile, atherogenic index of plasma (AIP), IL-33 and adiponectin levels were determined in patients and control groups. The results revealed highly significant increase in FBG, HbA1c, BMI, TCh, TG, LDL-c, VLDL-c and AIP. While reduce HDL-c, adiponectin and IL-33 levels were founded in postmenopausal women when comparing to control group. Furthermore, a positive correlation was observed in IL-33 with HbA1c, also with AIP, but a negative significant correlation between IL-33 and adiponectin, also between IL-33 and BMI in diabetic postmenopausal women group. Conclusion from the results of present work lead to suggest that higher reduction in IL-33 and adiponectin levels in diabetic postmenopausal women may be useful in predict action of cardiovascular disorders.
Keywords
Interleukin; Adiponectin; postmenopausal; atherogenicity

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