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Measurement of Adenosine Deaminase Concentration in Serum of Breast Cancer by HPLC before and after Chemotherapy in Hilla City | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 12, Issue 3, 2015, Pages 661-669 | ||
| Authors | ||
| Ali Mohammed Jawad; Mufeed Jalil Ewadh; Alaa Sadiq Al awad | ||
| Abstract | ||
| Breast cancer (BC) is a type of malignancy appeared in breast tissue , occurs in both premenopausal and also in postmenopausal women's. Adenosine deaminase (ADA) is an enzyme participate in metabolism of purine. However, the level of adenosine deaminase increased in most cancers patients and it could be of value before and after chemotherapy. A total of 280 patient with (BC) divided in two groups, first group (n=40) women with breast cancer without chemotherapy, second group (n= 240 ) women with breast cancer with chemotherapy, this group was divided into six groups according to the doses used (1st – 6th doses). The control group (n= 40) apparently healthy women's matched with patient group. Women with (BC) have a significant higher serum level of ADA than those who are not diseased (p<0.001) and even than those who received chemotherapy (p<0.05 ).So, this lead to a conclusion that; breast cancer women have higher level of ADA . ADA level decreased upon administration of chemotherapy. The objective of this study is to assess ADA status in women's BC receiving chemotherapy treatment. | ||
| Keywords | ||
| Breast Cancer; Adenosine deaminase; Chemotherapy; Higher Serum Level | ||
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