The Role of NT- Probnp in The Diagnostic Workup of Patient with Chronic Dyspnea of Unexplained Etiology

Obais Al-Naffi, Karim

	The Role of NT- Probnp in The Diagnostic Workup of Patient with Chronic Dyspnea of Unexplained Etiology
Medical Journal of Babylon
Article 1, Volume 12, Issue 3, 2015, Pages 711-720
Author
Karim Obais Al-Naffi
Abstract
Dyspnea is a common clinical complaint of diverse causes, it may be of acute or chronic onset. Diagnosis of dyspnea should depend on good history, proper physical examination with the logistic use of laboratory &radiological investigation. Yet some time, especially in patient with chronic dyspnea, we may be left with patient without clear clinical diagnosis. NT- proBNP is which is a hormone produced from the heart whenever there is stretch of cardiac muscle is proved of diagnostic value in acute dyspnea. This study is to examine the diagnostic value of NT-proBNP in the etiology of chronic dyspnea with unapparent clinical cause. From 425 patient presented complaining of chronic dyspnea, after full history, physical examination &conventional investigation, Sixty-two patient have no evident cause for their dyspnea. Those patients were studied to assess the value of NT- proBNP in the work up for the cause of their dyspnea &its relation to their BMI, age, HT, DM & IHD. Significant high level of NT- proBNP was found in patient who have higher grade of dyspnea &in those with chronic disease as HT, DM&IHD especially if they have IHD. Although many of the patient have high BMI but it does not significantly related to the level of dyspnea. NT- proBNP is a helpful diagnostic mean in patient with chronic dyspnea although other limitation factors as age, sex & BMI should considered.
Keywords
proBNP; Chronic Dyspnea

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