The effect of Monosodium glutamate to pregnant female rats and embryos

K. Tawfeeq, F.; H. Jarjees, E.

	The effect of Monosodium glutamate to pregnant female rats and embryos
Al-Anbar Journal of Veterinary Sciences
Article 1, Volume 6, Issue 2, 2013, Pages 100-107 PDF (653.14 K)
Authors
F. K. Tawfeeq; E. H. Jarjees
Abstract
The present study was designed to investigate the effect of Monosodium glutamate (MSG) 4g/kg. b. w, Vitamin A 25000 IU/kg. b.w, Monosodium glutamate and Vitamin A together (4g/ kg. b.w, 25000 IU/kg.b.w) respectively orally by gavage needle in female pregnant Wistar rats and their offspring. The study revealed a significant decrease in Ovarian weight in MSG, also in MSG and Vitamin A together treated groups compared with control, also there is a significant decrease in weight and length of animals pups treated with MSG in comparison with control, with a significant decrease in placental weight of MSG treated group in comparison with Vitamin A treated group, whereas there was a significant decrease (p<0.05) in placental diameter is observed in MSG treated group in comparison with control and other groups. The treated group with MSG alone and vitamin A alone caused a significant increase in pups number in comparison with MSG and vitamin A groups together, Also it has been observed that there was significant increase(p<0.05) in placental numbers in MSG treated group in comparison with vitamin A group, moreover a significant decrease (p<0.05) in follicle stimulating hormone level in animals treated with MSG in comparison with control and other groups with no changes in lutinizing, progesterone and estrogen levels in all treated groups. It was concluded that MSG have a bad effects on offspring and the vitamin A with the dose and duration used in this research can not overcome the negative effects caused by MSG.
Keywords
pregnant female rats and embryos; Monosodium glutamate

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