Breast Carcinoma in Young Woman :Pathological and Immunohistochemical Study

Salman Ejam, Sura

	Breast Carcinoma in Young Woman :Pathological and Immunohistochemical Study
Medical Journal of Babylon
Article 1, Volume 12, Issue 3, 2015, Pages 817-827
Author
Sura Salman Ejam
Abstract
The aim of study is to study the pathological types and the immunohistochemical properties of breast carcinoma young women and compared it with older women This study included 80 paraffin embedded samples from female patients with breast carcinoma which were collected randomly from period of November 2010- November 2013 in AL-Hilla Teaching hospital. The clinical informations were collected including ages of the patients, histopathological types, & tumor grades from clinical reports of the hospital. A manual avidin biotin peroxidase complex procedure (ABC) system was used in the imunohistochemical analysis (Dako Cytomation Copenhagen, Denmark). In this study, the histopathological examination of the 80 cases revealed that , 5 (6.25%) cases were of the pure in situ ductal type, 65 (81.25%) cases were of the invasive ductal carcinoma not otherwise specified, 7 (8.75%) cases were of the invasive lobular carcinoma, and 1 (1.25%) case was of each of the medullary, mucoid, squamous (metaplastic) types. In the 80 cases of breast carcinoma that were studied, ER expression was positive in 8 cases (17.39%), PR expression was positive in 22 cases (27.5%), HER2/neu expression was positive in 20 cases (23.75%). There were higher proportion of ER and Her2 negative breast carcinoma in early aged patients than the older patients so the early onset breast according to the immuno -histochemical parameters have the worse prognonsis than the late onset group.
Keywords
Estrogen; Progesterone; Her; breast carcinoma

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