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Frequency of HLA-DR3 Alleles and Pedigree Analysis for Patients with Thyroiditis | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 12, Issue 3, 2015, Pages 849-856 | ||
| Authors | ||
| Alaa Jawad Hassan; Eman Wahab Kadhum | ||
| Abstract | ||
| A study was performed to estimation the concentration of HLA-DR3 alleles and pedigree analysis in patients with thyroid diseases in Babylon province .The results showed that there was significantly increased (p<0.05) in frequency of HLA-DR alleles in all groups of patients (hyperthyroidism , hypothyroidism , euthyroidism and normal with family history ) compared with healthy subjects . Furthermore , the results reveals increased ratio of disease in females compared with males , also the ratio of thyroiditis patients were higher in second age categories compared with first and third age categories . The pedigree analysis showed genetic role in the frequency of disease depending on the genetic history of family , where more patients with thyroiditis were found in families, one of them (especially mother) or their uncles undergo from this disease . | ||
| Keywords | ||
| Autoimmunity; Thyroiditis; HLA; DR Alleles; Pedigree analysis | ||
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