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Synthesis and study the biological activity of Schiff base derivatives of1,3-Oxazepines | ||
| journal of the college of basic education | ||
| Article 1, Volume 14, Issue 62, 2010, Pages 9-14 | ||
| Author | ||
| Huda I. Ibrahim | ||
| Abstract | ||
| Reaction of m-nitrobenzaldehyde with semicarbazide hydrochloride in dry benzene give m-nitrophenyl semicarbazone (Schiff bases) . These Schiff bases were found to react smoothly with maleic anhydride , phthalic anhydride , 3-nitrophthalic anhydride and succnic anhydride to give seven membered heterocyclic system:1,3-Oxazepines. The new compounds characterized by elemental analysis, physical and spectral data. All the 1,3-Oxazpines have been screened for antibacterial activity against, Escherichia coli (G-), Staphylococcus aureus (G+) , Pseudomonas aureus (G-) .Some compounds were found to be active antibacterial. | ||
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