Study of Some Hematological Parameters and Determination of Glysated Hemoglobin in β-Thalassemia

Hussein Jawad  AL-Qaisi, Zyad; A.K. M, Wasan; Moneb Al-Rubae, Zaineb

	Study of Some Hematological Parameters and Determination of Glysated Hemoglobin in β-Thalassemia
journal of the college of basic education
Article 1, Volume 14, Issue 62, 2010, Pages 165-170
Authors
Zyad Hussein Jawad AL-Qaisi; Wasan A.K. M; Zaineb Moneb Al-Rubae
Abstract
The aim of the present study is to evaluate glysated hemoglobin (HbA1c) in major ,minor thalassemic patients and compare that with control,in order to investigate the possibility of using such parameters as marker in comparison with there levels in sera of normal control. Some hematological parameters as diagnostic factors for thalessemia were estimated in sera of 50 control, 50 minor and 50 major thalassemic patients.The age for the all subjects range from (4-18) .A significant elevation in the HbF % was found in major thalessemia with value of (90.33±28.22) comparing to minor group (2.56 ± 1.12) and control group (0.44 ± 0.02).The HbA1 % for control, minor and major thalassemic patients were (7.94 ± 0.57), (11.63 ± 1.38) and (14.83 ± 1.09) respectively. The value for HbA1c % increased also for all studied groups (5.95 ± 0.50), ( 9.04 ± 1.15 ) and (11.83 ± 0.86) for control, minor and major thalassemic patients respectively. A conclusion could be drawn from the results of present study that the significant elevation in HbA1c in serum of major thalassemic patients compared to control was found that shown the relation between β-globin ,glucose and iron which led to oxidative strees and insulin resistance that cause endothelial damage ,therefore, the evaluation of HbA1c needs further studies

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