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The hypoglycemic and hypolipidemicefficacy of Atorvastatin andFlaxseed oil in type 2 diabetic patients. | ||
| AL-yarmouk Journall | ||
| Article 1, Volume 0, Issue 1, 2015, Pages 14-29 | ||
| Authors | ||
| Haitham M. Kadhim; Faruk H Aljawad; Ashwaq Q. Gorji; Hashim M Hashim | ||
| Abstract | ||
| Background: Glycemic control and prevention of secondary complications are the most important aims of using pharmacological treatment in diabetes mellitus. Dyslipidemia is a modifiable CVD risk factor that remains largely uncontrolled in patients with type 2 diabetes. The administration of Flaxseed oil may improve tissue responses to insulin and increase the efficacy of drugs which act through this pathway like Sulfonylurea. Aim of the study: To investigate the effectiveness of Atorvastatin and Flaxseed oil that possess antioxidant and/or hypolipidemic effects on the changes that occur in patients with type 2 diabetes mellitus due to uncontrolled glycemic status. Patients and Methods: This study was carried out in The Specialized Center for Endocrinology and Diabetes, Baghdad on (43) diabetic patients (26 female and 17 male). All participants are selected after giving their informed consent, their age range 35-60 years , and have disease duration of 5-10 years. Patients allocated to 3 groups, first group was treated with Placebo (starch 50mg ; n=13) , second group was treated with (Atorvastatin 20mg/day; n=14), while third group was treated with (Flaxseed oil1000mg/day; n=16), in addition to the already given oral hypoglycemic agent (glibenclamide 15 mg/day) and dietary control for 12 Weeks. To each group, the following biochemical parameters were done at baseline ;after 6 weeks and after 12 weeks periods:Fasting serum glucose; glycated hemoglobin and lipid profile tests according to the standard methods. Results: Administration ofAtorvastatin was significantly increase FBS and HbA1c serum levels, with a high significant decrease in S. Ch. And significant decrease in S. TG with a high significant decrease in S. LDL. While administration ofFlaxseed oil significantly reduced serum FBS, HbA1C, s. Ch, TG, LDL levels, however, the effects on these parameters were variable between the studied groups. Conclusion: The administration of Atorvastatin may induce hyperglycemia despite of it'shypolipidemic effect, while Flaxseed oilwhen used as adjuvant therapy could improve both glycemic control and lipid profile in patients with type 2DM . | ||
| Keywords | ||
| Atorvastatin; Flaxseed oil; Lipid profile; Type | ||
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