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Hepatoprotective effects of zinc sulphate and silymarin against thallium-induced poisoning in rats | ||
| AL-yarmouk Journall | ||
| Article 1, Volume 0, Issue 1, 2015, Pages 42-57 | ||
| Authors | ||
| Saad B. Nashtar; Ahmed Abu Raghif; Faruk H. Al-Jawad; Khalifa E. Sharquie; Ph. D; ; | ||
| Abstract | ||
| Background: Thallium (Tl) is a heavy metal with its salts are highly toxic. This element is widely used in manufacture, and still being used as a rodenticide in some countries. Many occupational, accidental and criminal cases present to clinics all over the world. Thallium toxicity affects all body compartments including hepatic tissue. Objective: to study the hepatoprotective effects of zinc sulphate and silymarin therapy in rats poisoned with thallium. Methods: 48 albino rats of both sex were classified into 4 groups, each group contains 12 rats, first group animals were given only distilled water orally for 5 successive days, second group were given a single oral dose of thallium acetate (16 mg/ kg) followed by a daily oral dose of distilled water. Third group given the same oral dose of thallium followed by a daily dose of zinc sulphate solution (20 mg/kg) for 5 successive days. Fourth group rats were given the same oral dose of thallium acetate followed by a daily oral dose of silymarin solution (25 mg/kg) for 5 successive days. Serum transaminases (ALT, AST) and alkaline phosphatase were measured and hepatic tissue sections were taken for histopathological study. Results: rats treated with zinc sulphate and silymarin had shown significant changes in serological and histopathological results in comparison to normal and thallium groups. Conclusion: zinc sulphate and silymarin have hepatoprotective effects against induced thallium poisoning in rats. | ||
| Keywords | ||
| thallium; zinc sulphate; Silymarin; hepatoprotective | ||
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