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Effect of toprimate on blood glucose level and lipid profile in normal and diabetic rabbits | ||
| AL-yarmouk Journall | ||
| Article 1, Volume 0, Issue 1, 2015, Pages 58-68 | ||
| Authors | ||
| Mohammed Abdul Muttalib Abdul Bari; Msc . pharmacology Baghdad collage of pharmacy | ||
| Abstract | ||
| This study was performed on 72 normal and diabetic rabbits allocated to groups to evaluate the effect of anti-epileptic drug topiramate . Both Hyperglycemia and dyslipidemia, are concern with the disorders of chronic metabolic syndromes related to dysfunctional endocrine system , clinically referred to as diabetes mellitus (DM) . DM is defined and categorized on the basis of intrinsic and extrinsic causative factors. Physicians have used the antiepileptic topiramate to treat neuropathic pain in diabetic patient & bipolar disorder , This study was performed to evaluate the effects of anti-epileptic drugs (topiramate) when used in a dose dependent manner on induction of Cytchrom-P450 enzyme with diabetic disease on lipid profile in normal and diabetic rabbits . the obtained results in this study showed that topiramate in a dose of 50 mg/kg has no significant effect on blood cholesterol , LDL and HDL levels with the exception of triglyceride that show a significant changes in compare to both negative and positive control group and also in the same animal group between day 5 to day 20. | ||
| Keywords | ||
| topiramate; Lipid profile; epilepsy; diabetic rabbits | ||
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