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Difference between Pro- & Anti-Inflammatory Cytokines in Latent Autoimmune Diabetes of Adult (LADA) and Diabetes Mellitus Type2 (D.M.2) | ||
| Kerbala Journal of Medicine | ||
| Article 1, Volume 8, Issue 2, 2015, Pages 2252-2257 PDF (0 K) | ||
| Authors | ||
| Sawsan M. Jabbar AL-Hasnawi; Salman A. AL-Jiboury | ||
| Abstract | ||
| background: Immunological profile of LADA is not so clear, so detection ofcytokines is relevant to determine the extent and direction of immune responses. Objective: the aim of the study is to identify role of pro-& anti-inflammatory cytokines in diabetes progression and their relation with diabetes complications. Methodology: level of the pro-inflammatory cytokines IL-6 and IFN-γ and the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1RA) were estimated in 90 subjects (34 known LADA cases, 36 D.M.2 cases & 20 healthy control participants), participating patients were recruited from Diabetes outpatient clinic in AL-Hussein Teaching Hospital in Karbala from June, 2013 through January, 2014. A clinical questioner containing personal data, family history, type of diabetes, hemoglobin A1C( HA1C), body mass index (BMI), diabetes duration& complications of diabetes was obtained from all patients. Statistical analysis done by using the statistical package for social sciences (SPSS) software for windows, data of all participants were entered and analyzed with appropriate statistical tests. Results: levels of IL-6 & IL-1RA were significantly higher in D.M.2 and LADA cases than controls & both are associated with complications in D.M.2 patients, in addition to positive significant correlation between them. Regarding IFN-γ, it was significantly higher in LADA group than D.M.2 group. Discussion: Levels of IL-6 & IL-1RA are increased in complicated cases for both LADA & D.M.2 groups & IFN-γ is more in LADA group. Conclusion: up regulation of both pro- and anti-inflammatory mediators to ameliorate inflammation in pathogenesis of diabetes. Recommendation: Further studies on IL-1RA in diabetes are recommended to see the useful effects of IL-1RA in preserving β-cell function and its therapeutic role in both autoimmune & type 2 D.M. | ||
| Keywords | ||
| IFN; LADA; Body mass index; diabetes mellitus | ||
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