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Study of serum hormones and sialic acid levels of non-responsive infertile hyperprolactinemic women to medical therapy | ||
| journal of the college of basic education | ||
| Article 1, Volume 16, Issue 69, 2011, Pages 1-6 | ||
| Authors | ||
| Bader A.H; Jameel F.A | ||
| Abstract | ||
| The study was performed on (56) infertile hyperprolactinemic women who fail in response to the medical therapy age (20-35) years,and(30) normoprolactinemic women were performed as control . The patients were divided between two kinds of treatments ,as follow =group l consisted of patients treated with Bromocriptine alone ,5 mg of drug was taken orally for10 days , group 2were of treated patients with 5 mg of Bromocriptine associated with 50mg of clomiphene, the drugs were taken orally for 5 days respectively . Serum hormones and sialic acid levels were measured .The results indicated that ,PRL and SA levels were significantly higher ( p<0.0 5 ) in both groups 1 and 2 compared to control , while there is no difference (p<0.0 5 ) in FSH and LH levels of both groups 1 and 2 compared to control, except LH levels was higher in group 2 versus group 1 and control . In conclusion : 1- since SA is present just the structure of the two isforms of prolactin glycosylated prolactine (G-PRL) and big big prolactin (bbPRL ), it may be used as indicator to defined the type of elevated PRL and then , monitoring appropriate therapy . 2- the unappropriate treatment for these patients may be the cause of failure response | ||
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