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Immunohistochemical Expression of Hypoxia-Inducible Factor-1α in Triple Negative Breast Cancer | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 12, Issue 4, 2015, Pages 0-0 | ||
| Authors | ||
| Mahdi Jassim Muhammad Ali; Haider Abdul Ridha AL-Khafaji; Abbas Fadhil Hassoon | ||
| Abstract | ||
| Triple-negative breast cancer is a malignant neoplasm characterized by absent expression of estrogen, progesterone and human epidermal growth factor-2 receptors. Hypoxia-inducible factor-1 alpha is up-regulated under hypoxia and associated with induction of angiogenesis resulting in proliferation, aggressive tumor phenotype and metastasis. Determination of the potential role of Hypoxia-inducible factor-1 alpha in the development and conventional clinicopathologic factors, and to demonstrate their prognostic relevance in Triple-negative breast cancer. A pro and retrospective study of 281 female patients with breast cancer. The fifty four triple-negative breast cancer formalin-fixed, paraffin-embedded Specimenspresented from all cases were immuno-stained by Hypoxia-inducible factor-1 alpha Immunohistochemical marker. The age groups distributed from 23-85 years old, mean age 51.23±11.26 years. Overall cases, triple negative breast cancer presented in 19.2%; most frequently younger,grade III, tumor size ≥ 2 cm, and positive lymph node metastasis or recurrent more than other subtypes. Hypoxia-inducible factor-1 alpha expression was strongly associated and significantly differentwith grade (p=0.001), lymph node metastasis (p<0.001) and Ki-67 expression (p=0.003). Detected Hypoxia-inducible factor-1 alpha expression has an important role in pathogenesis, drug resistance and in uncontrolled proliferation cells or as important conductor of the worst prognosis in triple negative-breast cancer. | ||
| Keywords | ||
| Triple negative; Breast Cancer; HIF; and prognostic factors | ||
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