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Levels of Incretin Hormones in Subjects with Type 2 Diabetes in Different Grads of BMI | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 12, Issue 4, 2015, Pages 0-0 | ||
| Authors | ||
| Israa Habeeb Ibrahim; Haider Kamel Zaidan; Moshtak Abduladheem Wtwt | ||
| Abstract | ||
| Incretins are gut hormones that potentiate insulin secretion after meal ingestion in a glucose-dependent manner. There are different types of incretin hormones like GLP-1, GLP-2 and GIP. DPP-IV is the enzyme that deactivate incretin hormone in the blood. The aim of this study was to evaluate the relationship between obesity and incretin hormones in patients with type 2 diabetes.The study was included (107) patients : (62) males and (45) females from Al-Hussein Medical City in Karbala province and Marjan Medical City in Babylon province. The control for this study was (32) healthy subjects: (14) males and (18) females.BMI, Waist circumference, blood pressure , HbA1c, lipid profile, AIP, GLP-1, GLP-2 , GIP and DPP-Iv were measured to all patients and control.The resultsshow significant decrease in GLP-1 (P=0.018) and GLP-2 (P=0.028) and there was no differences in GIP (P=0.74) in patients group in comparison also there was significant increase in DPP-IV (P<0.001) in patients group in comparison with control group.According to BMI grades there was some decrease in GLP-1 and GLP-2 in obese subjects but there was no differences in GIP in comparison with lean control group. Also there was significant increase in DPP-IV in obese patients in comparison with lean control. We conclude that the decrease in incretin hormones may come mostly from the increase in DPP-IV enzyme that degrade them in the blood quickly and according to the relation with obesity, DPP-IV enzyme increase significantly in obese diabetic patients in comparison with healthy lean subjects. | ||
| Keywords | ||
| Incretins; diabetes mellitus; Obesity; GLP; DPP | ||
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