Effect of Acitretin on Serum Biomarkers Levels in Patients with Psoriasis

Hamed Alobaidi, Amina

	Effect of Acitretin on Serum Biomarkers Levels in Patients with Psoriasis
Medical Journal of Babylon
Article 1, Volume 12, Issue 4, 2015, Pages 0-0
Author
Amina Hamed Alobaidi
Abstract
Psoriasis is a multifactorial, chronic, inflammatory skin disease of unknown etiology, associated with cytokines and adipokines serum levels changes that may influence disease pathogenesis. To determine the effect of acitretin on serum IL-10, IL-23, adiponectin, Zn, Mg and copper levels in psoriasis patients. A case control study that include 50 psoriasis patients, conducted in Tikrit Teaching Hospital. They received acitretin orally for 4 weeks duration course. IL-10, IL-23, adiponectin, Zn, Cu and Mg in serum for all patients determined at the time of enrollement in the study and after 4 weeks of treatment with the drug. Acitretin reduced the mean PASI in 20 psoriatic patients from 20.97 before receiving treatment to 1.22 after receiving treatment (P=0.000). In addition, the mean serum levels for IL-10 reduced significantly (P=0.000) from (6.01±4.17) pg/ml before treatment to (1.85±0.54) pg/ml after treatment. Furthermore, Acitretin reduced the mean serum level for IL-23 from (72.08±34.14) pg/ml pre-treatment to (66.1±20.3) pg/ml, post-treatment (P=0.423). The mean serum levels of adiponectin in therapeutic group was lower (6.97±3.06) μg/ml than that of baseline value (8.9±3.96) μg/ml, but this result was statistically not significant (p=0.114). The mean serum levels of Zinc and copper in therapeutic group was lower than baseline value, but the difference was statistically not significant (p>0.05).
Keywords
psoriasis; Acitretin; Interleukin; Adiponectin; Zinc; copper; Magnesium

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