Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Iraqi Women with Type II DM

Fadhil Smaism, Maha; Jawad Hassani, A; Najla,

	Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Iraqi Women with Type II DM
Medical Journal of Babylon
Article 1, Volume 12, Issue 4, 2015, Pages 0-0
Authors
Maha Fadhil Smaism; a Jawad Hassani;
Abstract
Type 2 diabetes confers an increased morbidity and mortality dueto macrovascular complicationssuch as CVDfor which dyslipidemia is themajor contributor. This study was designed toexplore the role of non-HDLcandlipoprotein ratios as CVD riskmarker in diabetic population. It was acase –control study , 68 female uncontrolled (HbA1c ≥ 6.5) diabetic were selected, 34 were diabetic who were treatment(Goup A) and 34 werediabetic without treatment (Group B)and 34 were non-diabetic subjects as control group . The lipidprofile including TC, TG and HDLc were measured and calculation of lipoprotein ratios.Lipoprotein ratios were significantly higher in group A, Non-HDL(P<0.001), TC/HDL and TG/HDL(P<0.01), LDL/HDL(P<0.05) In group B; Non-HDLc(P<0.01), TC/HDL, TG/HDL and LDL/HDL(P<0.05) in contrast tocontrols. There is significantly positive correlation of TG/HDLc, TC/HDLc, LDL/HDLc and Non-HDLc with HOMA-IR in group A and in group B. Lipoprotein ratio provide a simple means of identifying insulin resistance which could be used as a possible risk factor ofCVD in uncontrolledtype 2 diabetic.
Keywords
Type II diabetes mellitus; triglyceride; Total Cholesterol; Lipoproteins; insulin resistance; Cardiovascular disease

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