Effect of Salvia officinalis L. (Sage) Aqueous extract  on Liver and Testicular Function of Diabetic Albino Male  Rats.

AL-Chalabi, M.M; Salah,; M.Shukri,; Hussein,; I.Mahmood,; Rana,; Luma.B.Khalid,

	Effect of Salvia officinalis L. (Sage) Aqueous extract on Liver and Testicular Function of Diabetic Albino Male Rats.
Journal of University of Babylon
Article 1, Volume 24, Issue 2, 2016, Pages 390-399
Authors
M.M AL-Chalabi; ; ; ; ; ;
Abstract
The study was current to examine the antidiabetic effects of administration of aqueous extracts of Salvia officinalis leaves in alloxan( 100 mg/kg) induced diabetic rats and reveal the effect of Salvia officinalis in the the liver and testicular function. The present study aimed to evaluate the effects of aqueous extracts of Sage leaves (Salvia officinalis L., Lamiaceae ), on the levels of blood glucose, plasma lipids profiles such as triglycerides (TG), total cholesterol (TC), high-density lipoproteins (HDL), low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL) in diabetic rats. The animals were rendered diabetic by a single intraperitoneal injection alloxan( 100 mg/kg). Twenty eight adult male albino rats of 7-9 weeks old weighting (240± 10 gm) were used for this study. They were kept for one week for proper acclimatization before starting the experiment under the same controlled laboratory conditions of illumination period (12h light/12h darkness), temperature at 22±2°C and maintained on standard diet and water. The aqueous Salvia officinalis extracts were injected intraperitonally at a dosage of 300 mg/kg for five weeks since the day after diabetes confirmation blood samples were obtained from heart. The results showed that i.p. injection with alloxan induced very highly significant elevation in mean of blood glucose levels of diabetic animals as compared with control group and sage administration groups. Diabetic rats also revealed highly significant elevation in, total cholesterol (TC), triacylglyceride (TAG), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) concurrent with highly significant reduction in high-density lipoprotein cholesterol (HDL-C) as compared with control group. administration of sage tea had no effect on normal rats. Animals treatment with sage to diabetic rats induced significant improvement in all testicular function parameters(total count, viability, motility and morphology), it reduced significantly blood glucose levels as well as induced significantly amelioration in lipid profile parameters as compared with non treated diabetic group. Therefore, it could be concluded that sage had a potent hypoglycemic activity, this effect may be attributed to its antioxidant activities. Results showed a significant decrease in Testosterone , LH , FSH levels in diabetic male rats compared with control male and sage with diabetic groups after 5 weeks from treated. The results obtained a significant increase in dead sperm , morphology abnormalities in diabetic male rats compared with control male ,Sage extract and Sag extract with diabetic
Keywords
Salvia officinalis L; diabetes mellitus; Hyperglycaemia; lipid profile; Rat; Alloxan monohydrate

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