Risk factors for cardiovascular diseases and metabolic syndrome in psoriatic patients: case - control study

Aljasim, Zaineb; A Dhaher, Samer

doi:10.33762/mjbu.2015.108447

	Risk factors for cardiovascular diseases and metabolic syndrome in psoriatic patients: case - control study
The Medical Journal of Basrah University
Article 1, Volume 33, Issue 2, 2015, Pages 100-106 PDF (0 K)
DOI: 10.33762/mjbu.2015.108447
Authors
Zaineb Aljasim; Samer A Dhaher
Abstract
Background: Psoriasis has an increased likelihood of comorbidities compared with healthy controls such as cardiovascular diseases and metabolic syndrome. Objectives: To investigate the risk factors that increases the incidence of cardiovascular diseases and metabolic syndrome in Iraqi patients with psoriasis. Patients & methods: a case- control prospective study enrolled 80 patients with psoriasis and 80 normal individuals as a control group. Psoriasis severity was assessed using PASI(psoriasis area severity index) score, in both groups, blood pressure, BMI(body mass index) & waist circumference were measured, laboratory tests including fasting blood sugar & lipid profile were done. For comparison between the 2 groups, Fisher s exact test were performed. Results: In psoriatic group, calculation of (BMI), showed that 19 (23.8%) were obese, 34 (42.5%) over weight, 27 (38.8%) normal weight. Thirty four patients (42.5%) had an elevated blood pressure, both were significantly correlated with the severity of psoriasis.44 (55%) have abnormal lipid profile, 17 (21.3%) elevated cholesterol, 17(21.3%) had raised LDL & 32 (40%) had low HDL. These were correlated with the severity of psoriasis. Eight (10%) patients had elevated VLDL & 13 (16.3 %) had elevated TG. Twelve (15%) patients had elevated FBS.33 (41.25%) patients were having Metabolic syndrome and the risk was increased with the duration of psoriasis. Comparing with the control group, psoriatic patients were at risk of developing hyperglycemia & hyperlipidemia with statistically significant elevation of fasting blood sugar, cholesterol, LDL, & reduced HDL. Conclusions: Compared with the control group, psoriatic patients in our population had an atherogenic lipid profile with increased prevalence of risk factors for cardiovascular diseases & metabolic syndrome & this was directly correlated with the severity and duration of the disease.

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