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Evaluation of Serum Apelin in Acute Coronary Syndrome Patients | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 57, Issue 4, 2015, Pages 326-328 | ||
| Authors | ||
| Nazar N. Abbas; Zina H. Abdul-Qahar; Bashar J. Hussein | ||
| Abstract | ||
| Background: Acute coronary syndrome refers to any group of clinical symptoms compatible with acute myocardial ischemia including unstable angina (UA), Non-ST-segment elevation myocardial infarction (NSTEMI) & ST-segment elevation myocardial infarction (STEMI). Apelin is a novel endogenous peptide with inotropic and vasodilatory properties, it was recently reported that serum measurements of apelin were similar to its immunohistochemical data in vessels and heart tissues. Objectives: This study aims to evaluate serum levels of apelin in patients with Acute Coronary Syndrome related to severity of presentation. Patients and Methods: The present study was conducted during the period from September 2014 until March 2015. Fifty-nine patients with ACS were included as (30 UA, 15 NSTEMI, & 14 STEMI) patients. Also the study included (28) apparently healthy persons served as control. Blood samples were obtained for measurements of Apelin by ELISA method. Results: Serum apelin levels were significantly decreased in whole group of patients with ACS (1846.1±320.9) ng/ml compared to control (2719.4±272.5) ng/ml (p< 0.05). Regarding patients' subgroups; serum apelin was lowest in STEMI (1729.0±480.0) ng/ml, NSTEMI (1816.0±289.0) ng/ml, & UA (1916.0±224.4) ng/ml when compared with control; respectively. Conclusion: Data obtained revealed a reduction in serum apelin levels in all patients groups especially STEMI, so it could be considered as a biochemical marker for evaluation of ACS. Keywords: Acute Coronary Syndrome, Unstable angina, ST-segment elevation MI, Non-ST- segment elevation MI, Apelin. | ||
| Keywords | ||
| Acute coronary syndrome; Unstable angina; segment elevation MI; non; Apelin; STEMI | ||
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